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SynKinase
Erlotinib hydrochloride
71
CHF
CHF 71.00
In stock
SYN-1039-M0011 mgCHF 71.00
SYN-1039-M0055 mgCHF 99.00
SYN-1039-M01010 mgCHF 128.00
SYN-1039-M05050 mgCHF 170.00
SYN-1039-M100100 mgCHF 206.00
| Product Details | |
|---|---|
| Synonyms | OSI774; CP-358774; Tarceva; NSC718781 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H23N3O4 . HCl |
| MW | 393.4 . 36.5 |
| CAS | 183319-69-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: EGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GTTBEUCJPZQMDZ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC(50) of 2nM against EGFR. It is >1000-fold more sensitive for EGFR than for c-Src or v-Abl.
Product References
- Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen: J.R. Johnson, et al.; Clin. Cancer Res. 11, 6414 (2005)
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