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SynKinase
Tandutinib
71
CHF
CHF 71.00
In stock
SYN-1088-M0011 mgCHF 71.00
SYN-1088-M0055 mgCHF 92.00
SYN-1088-M01010 mgCHF 106.00
SYN-1088-M05050 mgCHF 128.00
SYN-1088-M100100 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | CT53518; MLN518 |
| Product Type | Chemical |
| Properties | |
| Formula | C31H42N6O4 |
| MW | 562.7 |
| CAS | 387867-13-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PDGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | UXXQOJXBIDBUAC-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Tandutinib inhibits the auto-phosphorylation of FLT3 (FMS-Like Tyrosine kinase-3, IC(50) of 0.22µM), c-KIT and PDGF (platelet-derived growth factor), thereby inhibiting cellular proliferation and inducing apoptosis.
Product References
- CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML): L.M. Kelly, et al.; Cancer Cell 1, 421 (2002)
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