anti-Ubiquitin K48 Linkage, mAb (1001c)

CHF 388.00
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AG-20T-0209-C05050 µgCHF 388.00
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Product Details
Synonyms UBB; Ubiquitin B
Product Type Monoclonal Antibody
Clone 1001c
Isotype Rabbit IgG
Immunogen/Antigen K48-linkage from human ubiquitin.
Application Western Blot: (0.1-0.5µg/ml)
Crossreactivity All
Specificity Recognizes endogenous human proteins containing K48-linked polyubiquitin chains, but has no cross-reactivity to monoubiquitin or polyubiquitin of other linkages.
Purity Detail Protein A purified.
Formulation Liquid. In PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Declaration Manufactured by Boston Biochem
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Aliquot to avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
Polyubiquitin chains are composed of ubiquitin monomers that are covalently linked through isopeptide bonds (other than linear, or “Met1-linked” polyubiquitin). Isopeptides are formed between a lysine residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule. Seven of the seventy-six amino acids in ubiquitin are lysine residues that can participate in polyubiquitin chain formation. Linkage through specific lysine residues is thought to serve as a signal that affects protein degradation, signaling, trafficking, and other cellular processes. K48-linked polyubiquitin chains attached to substrate proteins often serve as a recognition sequence for targeting and destruction of the substrate by the 26S proteasome.
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