anti-MDA5 (mouse), pAb (AL180)

CHF 440.00
In stock
AG-25B-0001-R100100 µlCHF 440.00
More Information
Product Details
Synonyms Helicard; Melanoma Differentiation-associated Gene 5
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant mouse MDA5 (aa 2-208).
Application Immunohistochemistry: (frozen sections)
Western Blot
Crossreactivity Mouse
Specificity Recognizes mouse MDA5.
Formulation Liquid. Neat serum containing 0.02% sodium azide.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. MDA5, upon interaction with intracellular dsRNA (produced during viral replication), triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-κB, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-β and RANTES (CCL5). MDA5 is widely expressed at low levels. The expression is detected at higher levels in placenta, pancreas and spleen and barely in brain, testis and lung. Genetic variation in MDA5 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy.

Product References
  1. Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation: M. Kovacsovics, et al.; Curr. Biol. 12, 838 (2002)
  2. Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells: S. McCartney, et al.; J. Exp. Med. 206, 2967 (2009)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.