FNDC4 (rec.) (untagged)

CHF 270.00
In stock
AG-40B-0124-C01010 µgCHF 270.00
AG-40B-0124-C05050 µgCHF 850.00
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Product Details
Synonyms Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
Product Type Protein
Properties
Source/Host E. coli
Sequence FNDC4 (extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.
Crossreactivity Dog
Human
Monkey
Mouse
Rat
MW ~16kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml
Reconstitution 10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data Uni-Prot link Q9H6D8: FNDC4
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.

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