AG-CN2-0438-C500500 µgCHF 190.00
|Source/Host Chemicals||Isolated from Xestospongia sp.|
|Purity Chemicals||≥98% (HPLC)|
|Solubility||Soluble in DMSO, ethanol or methanol.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Antibiotic. Antibacterial against Gram positive and Gram negative bacteria.
- Exhibits chemotherapeutic activity. Blocks tumor cell invasion and restores cancer cell susceptibility to apoptosis in vitro.
- Uncouples vacuolar ATPases, inhibiting autophagy and tumor growth.
- Antimalaria, antifungal and antiviral agent.
- GSK-3β inhibitor.
- Anti-Alzheimer's agent. Decreased tau hyperphosphorylation.
- Anti-hyperlipidemic. Inhibits cholesterol ester formation and acyl-CoA:cholesterol acyl-transferase (ACAT) activity in vitro and decreases total cholesterol, triglycerides and LDL levels.
- Anti-atherosclerotic. Inhibits foam cell formation in macrophages.
- Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996)
- In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000)
- Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001)
- Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003)
- New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003)
- New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004)
- Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007)
- Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells: J.R. Palem, et al.; Planta Med. 77, 46 (2011)
- A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis: E.A. Guzman, et al.; Invest. New Drugs 29, 777 (2011)
- Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo: K. Eguchi, et al.; Bioorg. Med. Chem. 21, 3831 (2013)
- The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells: G. Kallifatidis, et al.; Mar. Drugs 11, 3500 (2013)
- AR-A 014418 used against GSK3beta downregulates expression of hnRNPA1 and SF2/ASF splicing factors: A.K. Yadav, et al.; J. Oncol. 2014, 695325 (2014)