CHF 95.00
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AG-CN2-0458-M0011 mgCHF 95.00
AG-CN2-0458-M0055 mgCHF 380.00
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Product Details
Synonyms Arglabine
Product Type Chemical


MW 246.3
CAS 84692-91-1
Source/Host Chemicals Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora.
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water.
Identity Determined by 1H-NMR.
Smiles [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Anticancer compound.
  • Farnesyltransferase inhibitor.
  • Potent anti-inflammatory agent.
  • NF-κB inhibitor.
  • Inflammasome inhibitor.
  • Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Product References
  1. In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
  2. Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
  3. Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
  4. Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
  5. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
  6. Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
  7. Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)
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