Ganglioside GT1b . trisodium salt

CHF 150.00
In stock
AG-CN2-9006-M0011 mgCHF 150.00
AG-CN2-9006-M0055 mgCHF 450.00
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Product Details
Synonyms GT1b . 3Na; Trisialoganglioside GT1b . 3Na
Product Type Chemical
Properties
Formula

C95H162N5O47 . 3Na

MW 2126.3 . 69.0 (calculated on sphingosine
C18:1 and stearic acid)
Sequence

Structure: IV3Neu5AcII3NeuAc2GgOse4Cer; α-Neu5Ac-(2-3)-β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90%

CAS 59247-13-1
Source/Host Chemicals Isolated from bovine brain.
Purity Chemicals ≥98% (TLC)
Solubility Soluble in water (micellar aggregates) or chloroform:methanol (2:1).
Formulation Lyophilized
Endotoxin Content Not detectable.
Identity Determined by 1H-NMR, MS and HPTLC.
InChi Key XWMACUIMZLECSZ-UVHDICHMSA-K
Smiles [Na+].[Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@H]1[C@H](O)C(CO)O[C@@H](OC2[C@@H](O)[C@H](CO)O[C@H](O[C@H]3C(CO)O[C@@H](O[C@H]4C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]4CO)C(O)[C@H]3O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(CO)O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(O)CO)C([O-])=O)C([O-])=O)C2NC(C)=O)C1O)C([O-])=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GT1b binds botulinum and tetanus neurotoxins and it prevents neurotoxicity of glutamate on neuronal cells.

Product References
  1. Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982).
  2. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof: C.L. Schengrund, et al.; J. Neurochem. 57, 1024 (1991)
  3. Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)
  4. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett. 517, 140 (2012)
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