120 CHF CHF 120.00
AG-CR1-3630-M0011 mgCHF 120.00
AG-CR1-3630-M0055 mgCHF 480.00
|Purity Chemicals||≥98% (HPLC)|
|Solubility||Soluble in DMSO (20mM).|
|Identity||Determined by NMR.|
|Other Product Data||NOTE: Prepare a 20mM solution in pure anhydrous DMSO. Prior to performing biological experiments we recommend to make dilutions of the stock solution into aqueous buffers (1mM solution of MMG-0358 in a 95% buffer/5% DMSO mixture).|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor.
- Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
- Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)
- Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)