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AdipoGen Life Sciences
MMG-0358
90
CHF
CHF 90.00
In stock
AG-CR1-3630-M0011 mgCHF 90.00
AG-CR1-3630-M0055 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | 4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H6ClN3O |
| MW | 195.6 |
| CAS | 1378976-02-3 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO (20mM). |
| Identity | Determined by NMR. |
| Other Product Data |
NOTE: Prepare a 20mM solution in pure anhydrous DMSO. Prior to performing biological experiments we recommend to make dilutions of the stock solution into aqueous buffers (1mM solution of MMG-0358 in a 95% buffer/5% DMSO mixture). |
| InChi Key | NBDFMTBYKCBTSW-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(Cl)C=C1)C1=CN=NN1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor.
- Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
Product References
- Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)
- Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)
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