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AdipoGen Life Sciences
Fipronil
65
CHF
CHF 65.00
In stock
AG-CR1-3648-M100100 mgCHF 65.00
AG-CR1-3648-G0011 gCHF 130.00
| Product Details | |
|---|---|
| Synonyms | Fluocyanobenpyrazole; Termidor; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethanesulfinyl)-1H-pyrazole-3-carbonitrile |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H4Cl2F6N4OS |
| MW | 437.2 |
| CAS | 120068-37-3 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to yellow solid. |
| Solubility | Soluble in DMSO, methanol, ethanol or acetone. Insoluble in water. |
| InChi Key | ZOCSXAVNDGMNBV-UHFFFAOYSA-N |
| Smiles | ClC1=C(N2N=C(C#N)C(S(C(F)(F)F)=O)=C2N)C(Cl)=CC(C(F)(F)F)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Alzheimer inducing agent (Alzheimerogen).
- Potent GABA receptor α-4 subunit and β-3 subunit inhibitor.
- Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles.
- Induces oxidative stress in mouse kidney and brain.
- Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
Product References
- Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel: L.M. Cole, et al.; Pestic. Biochem. Physiol. 46, 47 (1993)
- Actions of the insecticide fipronil, on dieldrin-sensitive and -resistant GABA receptors of Drosophila melanogaster: A.M. Hosie, et al.; Br. J. Pharmacol. 115, 909 (1995)
- Ion channels: molecular targets of neuroactive insecticides: V. Raymond-Delpech, et al.; Invert. Neurosci. 5, 119 (2005)
- Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals: T. Narahashi, et al.: Pestic. Biochem. Physiol. 97, 149 (2010)
- Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C: P.C. Badgujar, et al.; Pestic. Biochem. Physiol. 118, 10 (2015)
- Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration: B.L. Pearson, et al.; Nat. Commun. (2015)
- Specific triazine herbicides induce amyloid-β42 production: E. Portelius, et al.; J. Alzheimers Dis. 54, 1593 (2016)
- Impact of environmental chemicals on the transcriptome of primary human hepatocytes: Potential for health effects: R.D. Mitchell, et al.; J. Biochem. Mol. Toxicol. 30, 375 (2016)
- Muscarinic Acetylcholine Receptor Activation Synergizes the Knockdown and Toxicity of GABA-Gated Chloride Channel Insecticides: N. Xie & A.D. Gross; Pest Manag. Sci. ahead of print (2022)
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