Bafilomycin A1 (high purity)

CHF 110.00
In stock
BVT-0252-C100100 µgCHF 110.00
BVT-0252-M0011 mgCHF 280.00
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Product Details
Synonyms NSC381866
Product Type Chemical
Formula C35H58O9
MW 622.8
CAS 88899-55-2
Source/Host Chemicals Isolated from Streptomyces griseus.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in DMSO, 100% ethanol or methanol.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Macrolide antibiotic.
  • Specific vacuolar-type H+-ATPase inhibitor.
  • Distinguishes among different types of ATPases.
  • Inhibitor of endosomal, lysosomal and vacuolar acidification.
  • Prevents lysosomal Ca2+ uptake.
  • Inhibitor of autophagic degradation by rising pH and thus inactivating the lysosomal acid hydrolases.
  • Neuroprotective.
Product References
  1. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984)
  2. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988)
  3. Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990)
  4. Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990)
  5. Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991)
  6. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991)
  7. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993)
  8. Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995)
  9. Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), (Review)
  10. Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006)
  11. Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling: A. Thyssen, et al.; PNAS 107, 15258 (2010)
  12. Low-dose Bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction: V.N. Pivtoraiko, et al.; J. Neurochem. 114, 1193 (2010)
  13. Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption -implications for osteoclast quality: A.V. Neutzsky-Wulff, et al.; BMC Musculoskeletal Disorders 11, 109 (2010)
  14. Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes: C.I. Lopez Sanjurjo, et al.; PLoS One 9, e111275/1 (2014)
  15. Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells: Z. Xie, et al.; Mol. Med. Rep. 10, 1103 (2014)
  16. Comparison of the chemoimmunotherapeutic effect of doxorubicin and bafilomycin-A1 in mouse neuroblastoma cells: S. Inoue, et al.; Gan To Kagaku Ryoho. Cancer & Chemotherapy 41, 617 (2014)
  17. Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations Bafilomycin A1: B. Y, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 308, L270 (2015)
  18. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia: N. Yuan, et al.; Haematologica 100, 345 (2015)
  19. The protective effect of bafilomycin A1 against cobalt nanoparticle-induced cytotoxity and aseptic inflammation in macrophages in vitro: S. Wang, et al.; Biol. Trace Elem. Res. (2015)
  20. Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations Bafilomycin A1: B. Yeganeh, et al.; Am. J. Physiol. 308, L270 (2015)
  21. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus: T. Kimura, et al.; Acta Neuropathol. Comm. 5, 67 (2017)
  22. Molecular mechanisms of Streptococcus  pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination: M. Ogawa, et al.; Cell Microbiol., ahead of print (2018)
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