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BioViotica
Manumycin B
115
CHF
CHF 115.00
In stock
BVT-0264-M0011 mgCHF 115.00
| Product Details | |
|---|---|
| Synonyms | UCF1A; N98-1272A |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H34N2O7 |
| MW | 510.6 |
| CAS | 139023-58-8 |
| Source/Host Chemicals | Isolated from Streptomyces parvulus. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow to brown powder. |
| Solubility | Soluble in DMSO, methanol or chloroform. |
| Identity | Determined by 1H-NMR and UV. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | ZGICGDCGECBVTD-LOWJZYKPSA-N |
| Smiles | CCCC[C@@H](C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@@H]2O[C@@H]2C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution protect from light at -20°C. Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Antibacterial. Active against Gram-positive bacteria.
- Rasfarnesyltransferase inhibitor.
- Apoptosis (Caspase-1) inhibitor.
- AChE inhibitor.
- Anti-inflammatory.
Product References
- New compounds of the manumycin group of antibiotics and a facilitated route for their structure elucidation: I. Sattler, et al.; J. Org. Chem. 58, 6583 (1993)
- Identification of ras farnesyltransferase inhibitors by microbial screening: M. Hara, et al.; PNAS 90, 2281 (1993)
- TMC-1 A, B, C and D, new antibiotics of the Manumycin group produced by Streptomyces sp.: J. Kohno, et al.; J. Antibiot. 49, 1212 (1996)
- EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. III. Biochemical properties of EI-1511-3, -5 and EI-1625-2: T. Tanaka, et al.; J. Antibiot. 49, 1085 (1996)
- The manumycin-group metabolites: I. Sattler, et al.; Nat. Prod. Rep. 15, 221 (1998) (Review)
- The first total synthesis of a type II manumycin antibiotic, (+)-TMC-1 A: the total syntheses of (-)-LL-C10037β and(+)-manumycin B: J.J. Cronjé Grové, et al.; Chem. Commun. 1999, 421 (1999)
- Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites ofan actinomycete strain: Z.-H. Zheng, et al.; J. Enzyme Inh. Med. Chem. 22, 43 (2007)
- Inhibition of Pro-Inflammatory Cytokines by Metabolites of Streptomycetes—A Potential Alternative to Current Anti-Inflammatory Drugs? J. Hrdy, et al.; Microorg. 8, 621 (2020)
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