Aphidicolin 17-acetate

CHF 120.00
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BVT-0337-C250250 µgCHF 120.00
 
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Product Details
Synonyms 17-O-Acetylaphidicolin; Aphidicolin 17-monoacetate
Product Type Chemical
Properties
Formula C22H36O5
MW 380.5
CAS 51103-57-2
Source/Host Chemicals Isolated from Phoma sp. BS 7210.
Purity Chemicals ≥96% (HPLC, 1H-NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key GAPINCSXTLCIPV-BORIEPGUSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Phytotoxin (inhibits root growth of seeding).
  • Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis (competition with dCTP).
Product References
  1. Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
  2. 3-Deoxyaphidicolin and aphidicolin analogues as phytotoxin from Phoma betae: A. Ichihara, et al.; Agric. Biol. Chem. 48, 1687 (1984)
  3. Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase alpha in vitro: S. Hiranuma, et al.; Chem. Pharm. Bull. 35, 1641 (1987)
  4. Inhibition of DNA polymerase alpha by aphidicolin derivatives: L. Arabshahi, et al.; Nucleic Acids Res. 16, 5107 (1988)
  5. Aphidicolin synthetic studies: a stereocontrolled end game: C. Rizzo, et al.; J. Chem. Soc. 5, 969 (1991)
  6. Metabolites from Phoma sp. 7210, associated with Aizoon canariense: J. Dai, et al.; Nat. Prod. Comm. 5, 1175 (2010)
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