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BioViotica
Pyridomycin
325
CHF
CHF 325.00
In stock
BVT-0455-M0011 mgCHF 325.00
| Product Details | |
|---|---|
| Synonyms | Antibiotic U 24544; Erizomycin; NSC 246134 |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H32N4O8 |
| MW | 540.6 |
| CAS | 18791-21-4 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (1H-NMR, HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, methanol, water, dichloromethane or acetone. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | WHIKSLGSXKIHCA-IGCCMALHSA-N |
| Smiles | CC\C(C)=C1/OC(=O)[C@H](C)[C@H](O)[C@H](CC2=CC=CN=C2)NC(=O)[C@@H](NC(=O)C2=C(O)C=CC=N2)[C@@H](C)OC1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cyclodepsipeptide antibiotic. Unusual 12-membered macrocyclic depsipeptide comprises three unique subunits incorporating two substituted pyridines.
- Potent antitubercular agent.
- Inhibitor of NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis.
- Shown to be active against isoniazid-resistant mycobacteria.
Product References
- A new antibiotic, pyridomycin: K. Maeda, et al.; J. Antibiot. (Tokyo) 6, 140 (1953)
- Structure of pyridomycin: G. Koyama, et al.; Tetrahedron Lett. 37, 3587 (1967)
- Chemistry of pyridomycin: H. Ogawara, et al.; Chem. Pharm. Bull. 16, 679 (1968)
- Synthetic studies of pyridomycin. V. Total synthesis of pyridomycin: M. Kinoshita, et al.; Tetrahedron Lett. 30, 7419 (1989)
- Identification and characterization of the pyridomycin biosynthetic gene cluster of streptomyces pyridomyceticus NRRL B-2517: T. Huang, et al.; J. Biol. Chem. 286, 20648 (2011)
- Towards a new tuberculosis drug: pyridomycin - nature's isoniazid: R. C. Hartkoorn, et al.; EMBO Mol. Medicine 4, 1032 (2012)
- Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA: R. C. Hartkoorn, et al.; Nat. Chem. Biol. 10, 96 (2014)
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