Bafilomycin D (high purity)

CHF 200.00
In stock
BVT-0475-M0011 mgCHF 200.00
BVT-0475-M0055 mgCHF 680.00
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Product Details
Synonyms Tubamycin; Antibiotic 3D5
Product Type Chemical
Properties
Formula C35H56O8
MW 604.8
CAS 98813-13-9
Source/Host Chemicals Semi-synthetic product formed from Bafilomycin B1.
Purity Chemicals ≥98% (HPLC)
Appearance Off-white to yellow solid.
Solubility Soluble in DMSO, 100% ethanol, methanol, acetone or dichloromethane.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key ZKOTUWJMGBWBEO-YXTSRGFTSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Macrolide antibiotic. Bafilomycin derivative, in which the characteristic hemiketal portion has been opened.
  • Potent and specific vacuolar-type H+-ATPase inhibitor (V-ATPase).
  • Antiproliferative agent against selected human glioma cell lines.
  • Cytoxic activity. Active against Gram-positive bacteria and plant pathogen fungi.
  • Shows weak insecticidal and anti-nematodic activity.
Product References
  1. The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin: A. Kretschmer, et al.; Agric. Biol. Chem. 49, 2509 (1985)
  2. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Droese, et al.; Biochem. 32, 3902 (1993)
  3. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995)
  4. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Droese & K. Altendorf; J. Exp. Biol. 200, 1 (1997)
  5. Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups: M. G. O'Shea, et al.; J. Antibiot. 50, 1073 (1997)
  6. Bafilomycins and odoriferous sesquiterpenoids from Streptomyces albolongus isolated from Elephas maximus feces: N. Ding, et al.; J. Nat. Prod. 79, 799 (2016)
  7. Bioactive bafilomycins and a new N -arylpyrazinone derivative from marine-derived Streptomyces sp. HZP-2216E: Z. Zhang, et al.; Planta Med. (Epub ahead of Print) (2017)
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