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Chemodex
(S)-(+)-Naproxene
34
CHF
CHF 34.00
In stock
CDX-N0061-G0011 gCHF 34.00
CDX-N0061-G01010 gCHF 102.00
| Product Details | |
|---|---|
| Synonyms | Naprosyn; Equiproxen; Laraflex; (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid |
| Product Type | Chemical |
| Properties | |
| Formula | C14H14O3 |
| MW | 230.26 |
| CAS | 22204-53-1 |
| RTECS | UF5275000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate or tetrahydrofuran. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | CMWTZPSULFXXJA-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2C=C(C=CC2=C1)[C@H](C)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
Product References
(1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970) | (2) R.N. Brogden, et al.; Drugs 18, 241-277 (1979) | (3) W.F. Kean, et al.; J. Pharm. Sci. 78, 324 (1989) | (4) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010) | (5) T. Takeda, et al.; J. Phys. Chem. B. 114, 15394 (2010) | (6) F. Dimiza, et al.; J. Inorg. Biochem. 105, 476 (2011)
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