(S)-(+)-Naproxene

CHF 31.00
In stock
CDX-N0061-G0011 gCHF 31.00
CDX-N0061-G01010 gCHF 93.00
 
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Product Details
Synonyms Naprosyn; Equiproxen; Laraflex; (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid
Product Type Chemical
Properties
Formula C14H14O3
MW 230.26
CAS 22204-53-1
RTECS UF5275000
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance White powder.
Solubility Soluble in water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate or tetrahydrofuran.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key CMWTZPSULFXXJA-UHFFFAOYSA-N
Smiles COC1=CC=C2C=C(C=CC2=C1)[C@H](C)C(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
Product References
(1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970) | (2) R.N. Brogden, et al.; Drugs 18, 241-277 (1979) | (3) W.F. Kean, et al.; J. Pharm. Sci. 78, 324 (1989) | (4) K.C. Duggan, et al.; J. Biol. Chem. 285, 34950 (2010) | (5) T. Takeda, et al.; J. Phys. Chem. B. 114, 15394 (2010) | (6) F. Dimiza, et al.; J. Inorg. Biochem. 105, 476 (2011)
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