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FGF-19 (human) (rec.) (His)
230
CHF
CHF 230.00
In stock
CHI-AG-40A-0111-C01010 µgCHF 230.00
CHI-AG-40A-0111-C05050 µgCHF 490.00
Product Details | |
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Synonyms | Fibroblast Growth Factor 19 |
Product Type | Protein |
Properties | |
Source/Host | HEK 293 cells |
Sequence |
The extracellular domain of human FGF-19 (aa 25-216) is fused at the C-terminus to a His-tag. |
Crossreactivity | Human |
MW | ~22kDa (SDS-PAGE) |
Purity | ≥90% (SDS-PAGE) |
Endotoxin Content | <0.06EU/μg purified protein (LAL test). |
Reconstitution |
10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml. 50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration. |
Formulation | Lyophilized from 0.2μm-filtered solution in 1x PBS. |
Other Product Data |
UniProt link AAH17664.1: FGF-19 (human) |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.