FGF-19 (human) (rec.) (His)
|Synonyms||Fibroblast Growth Factor 19|
|Source/Host||HEK 293 cells|
The extracellular domain of human FGF-19 (aa 25-216) is fused at the C-terminus to a His-tag.
|Endotoxin Content||<0.06EU/μg purified protein (LAL test).|
10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml.
50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
|Formulation||Lyophilized from 0.2μm-filtered solution in 1x PBS.|
|Other Product Data||
UniProt link AAH17664.1: FGF-19 (human)
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.