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FGF-19 (human) (rec.) (His)
240
CHF
CHF 240.00
In stock
CHI-AG-40A-0111-C01010 µgCHF 240.00
CHI-AG-40A-0111-C05050 µgCHF 500.00
| Product Details | |
|---|---|
| Synonyms | Fibroblast Growth Factor 19 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human FGF-19 (aa 25-216) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~22kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.06EU/μg purified protein (LAL test). |
| Reconstitution |
10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml. 50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 1x PBS. |
| Other Product Data |
UniProt link AAH17664.1: FGF-19 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
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