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GPX5 (human) (rec.)
280
CHF
CHF 280.00
In stock
CHI-AG-40A-0169-C01010 µgCHF 280.00
CHI-AG-40A-0169-C05050 µgCHF 770.00
| Product Details | |
|---|---|
| Synonyms | HEL-S-75p; Glutathione Peroxidase 5; GSHPx-5; Epididymal Secretory Glutathione Peroxidase; EGLP |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human GPX5 (aa 24-221) is fused at the C-terminus to a FLAG®-tag. |
| Crossreactivity | Human |
| MW | ~25kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.06EU/μg purified protein (LAL test). |
| Reconstitution |
10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml. 50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 1X PBS. |
| Other Product Data |
NCBI link NP_001500.1: GPX5 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Glutathione peroxidase 5 (GPX5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene. GPX5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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