IL-37 (aa 46-218) (human) (rec.) (His)

CHF 280.00
In stock
CHI-AG-40A-0174-C01010 µgCHF 280.00
CHI-AG-40A-0174-C05050 µgCHF 770.00
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Product Details
Synonyms Interleukin-1 Family Member 7; IL-1F7; FIL1 zeta; IL-1X; Interleukin-1 Homolog 4; IL-1H4; Interleukin-1 zeta; IL-1 zeta; IL-1RP1; IL1F7; FIL1Z, IL1H4, IL1RP1
Product Type Protein
Source/Host E. coli
Sequence Human IL-37 (aa 46-218) is fused at the C-terminus to a His-tag.
Crossreactivity Human
MW ~20kDa (SDS-PAGE)
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.1EU/μg purified protein (LAL test; Lonza).
Reconstitution 10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml.
50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in 1X PBS.
Other Product Data NCBI link NP_055254: IL-37 (human)
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.

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