CCL2 (human):Fc (human) (rec.)

CHF 210.00
In stock
CHI-HF-210CCL2-C01010 µgCHF 210.00
CHI-HF-210CCL2-C05050 µgCHF 440.00
 
More Information
Product Details
Synonyms C-C Motif Chemokine 2; HC11; MCAF; Monocyte Chemotactic and Activating Factor; MCP1; Monocyte Chemotactic Protein 1; Scya2; Small-inducible Cytokine A2; JE; Monocyte Secretory Protein JE; SMC-CF; Sigje
Product Type Protein
Properties
Source/Host CHO cells
Sequence The extracellular domain of human CCL2 (aa 24-99) is fused to the N-terminus of the Fc region of human IgG1.
Crossreactivity Human
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.06EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute 10µg vial in 100µl sterile water.
Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Other Product Data NCBI reference NP_002973.1: CCL2 (human)
Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
CCL2, also called monocyte chemotactic protein-1 (MCP-1), is a member of the C-C or β chemokine family that is best known as a chemotactic agent for mononuclear cells. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.