CD1D (human):Fc (human) (rec.)
|Source/Host||HEK 293 cells|
The extracellular domain of human CD1D [R3G1] (aa 20-301) is fused to the N-terminus of the Fc region of human IgG1.
|Endotoxin Content||<5EU/mg protein (LAL test; Lonza).|
Reconstitute at 1mg/ml in sterile water.
Add 1X PBS to the desired protein concentration.
|Formulation||Lyophilized from 0.2μm-filtered solution in PBS.|
|Protein Negative Control|
|Other Product Data||
NCBI reference AAH27926.1: CD1D (human)
|Declaration||Manufactured by Chimerigen.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
Human T-cell surface glycoprotein CD1d, as known as R3G1, is a non-polymorphic MHC-like molecule which contains one Ig-like (immunoglobulin-like) domain, shares 65% and 68% aa sequence identity with mouse and rat CD1D, respectively. The CD1 family of antigen presenting molecules consists of five members, CD1A, CD1B, CD1C, CD1D, and CD1E. CD1D is expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. It is highly expressed in premalignant and early myeloma, with disease progression its expression is reduced and eventually in advanced stages and myeloma cell lines is lost altogether, suggesting that CD1D impacts negatively on myeloma cell survival. Human CD1D molecules bind a surprising diversity of lipid structures within the secretory pathway, including compounds that have been reported to play roles in cancer, autoimmune diseases, lipid signaling, and cell death.