CD1D (human):Fc (human) (rec.)

Human T-cell surface glycoprotein CD1d, as known as R3G1, is a non-polymorphic MHC-like molecule which contains one Ig-like (immunoglobulin-like) domain, shares 65% and 68% aa sequence identity with mouse and rat CD1D, respectively. The CD1 family of antigen presenting molecules consists of five members, CD1A, CD1B, CD1C, CD1D, and CD1E. CD1D is expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. It is highly expressed in premalignant and early myeloma, with disease progression its expression is reduced and eventually in advanced stages and myeloma cell lines is lost altogether, suggesting that CD1D impacts negatively on myeloma cell survival. Human CD1D molecules bind a surprising diversity of lipid structures within the secretory pathway, including compounds that have been reported to play roles in cancer, autoimmune diseases, lipid signaling, and cell death.