CD1D (human):Fc (human) (rec.)

CHF 380.00
In stock
CHI-HF-210CD1D-C05050 µgCHF 380.00
More Information
Product Details
Synonyms R3G1
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

The extracellular domain of human CD1D [R3G1] (aa 20-301) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Human
MW ~75kDa
Purity ≥98% (SDS-PAGE)
Endotoxin Content <5EU/mg protein (LAL test; Lonza).
Reconstitution Reconstitute at 1mg/ml in sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference AAH27926.1: CD1D (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Human T-cell surface glycoprotein CD1d, as known as R3G1, is a non-polymorphic MHC-like molecule which contains one Ig-like (immunoglobulin-like) domain, shares 65% and 68% aa sequence identity with mouse and rat CD1D, respectively. The CD1 family of antigen presenting molecules consists of five members, CD1A, CD1B, CD1C, CD1D, and CD1E. CD1D is expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. It is highly expressed in premalignant and early myeloma, with disease progression its expression is reduced and eventually in advanced stages and myeloma cell lines is lost altogether, suggesting that CD1D impacts negatively on myeloma cell survival. Human CD1D molecules bind a surprising diversity of lipid structures within the secretory pathway, including compounds that have been reported to play roles in cancer, autoimmune diseases, lipid signaling, and cell death.

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