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IL-10 (human) (rec.) (untagged)
280
CHF
CHF 280.00
In stock
CHI-HR-20610-C01010 µgCHF 280.00
CHI-HR-20610-C05050 µgCHF 770.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-10; Cytokine Synthesis Inhibitory Factor; CSIF |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human IL-10 (aa 19-178) with a N-terminal Met. |
| Crossreactivity | Human |
| Biological Activity |
Immobilized human IL-10 at 10µg/ml (100µl/well) can bind Cynomolgus IL-10RA-Fc. The EC50 of Cynomolgus IL-10RA-Fc is 0.24-0.56µg/ml. |
| MW | ~18kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg protein (LAL test; Lonza). |
| Reconstitution |
Reconstitute 10µg vial with 100 µl sterile water to a concentration of 0.1mg/ml. Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5mg/ml. Further dilute in other aqueous solutions. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 20mM Tris, 20mM NaCl, pH8.7. |
| Other Product Data |
NCBI reference NP_000563.1: IL-10 (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -80°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
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