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IL-22 (mouse):Fc (mouse) (rec.) (non-lytic)
350
CHF
CHF 350.00
In stock
CHI-MF-12022-C02525 µgCHF 350.00
CHI-MF-12022-C05050 µgCHF 520.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-22; IL-10-related T Cell-derived-inducible Factor |
| Product Type | Protein |
| Properties | |
| Source/Host | CHO cells |
| Sequence |
The extracellular domain of mouse IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. |
| Crossreactivity | Mouse |
| Biological Activity |
Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg. |
| MW | ~40kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.001EU/μg protein (LAL test; Lonza). |
| Reconstitution |
Reconstitute 25µg vial in 250µl sterile water. Reconstitute 50µg vial in 50µl sterile water. Add 1X PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Protein Negative Control | |
| Other Product Data |
Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (CRF29) and IL-10Rβ (CRF24), belonging to the class II cytokine receptor family.
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