IL-22 (mouse):Fc (mouse) (rec.) (non-lytic)

CHF 350.00
In stock
CHI-MF-12022-C02525 µgCHF 350.00
CHI-MF-12022-C05050 µgCHF 520.00
 
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Product Details
Synonyms Interleukin-22; IL-10-related T Cell-derived-inducible Factor
Product Type Protein
Properties
Source/Host CHO cells
Sequence The extracellular domain of mouse IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
Crossreactivity Mouse
Biological Activity Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg.
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute 25µg vial in 250µl sterile water.
Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Other Product Data Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

NCBI reference NP_058667.1: IL-22 (mouse)
Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (CRF29) and IL-10Rβ (CRF24), belonging to the class II cytokine receptor family.
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