IL-6Rβ [GP130] (rat):Fc (human) (rec.)
|Synonyms||CD130; gp130; Interleukin-6 receptor subunit beta; IL6RB|
|Source/Host||HEK 293 cells|
The extracellular domain of rat IL-6Rβ (aa 23-618) is fused to the N-terminus of the Fc region of human IgG1.
Measured by its binding ability in a functional ELISA.
|Endotoxin Content||<5EU/mg protein (LAL test; Lonza).|
Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
|Formulation||Lyophilized from 0.2μm-filtered solution in PBS.|
|Protein Negative Control|
|Other Product Data||
NCBI reference NP_001008725.2: IL-6Rβ (human)
|Declaration||Manufactured by Chimerigen.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
gp130 (also known as Glycoprotein 130, IL6ST, IL6-beta or CD130) is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.