IL-6Rβ [GP130] (rat):Fc (human) (rec.)

CHF 435.00
In stock
CHI-RF-311GP130-C05050 µgCHF 435.00
More Information
Product Details
Synonyms CD130; gp130; Interleukin-6 receptor subunit beta; IL6RB
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

The extracellular domain of rat IL-6Rβ (aa 23-618) is fused to the N-terminus of the Fc region of human IgG1.

Crossreactivity Rat
Biological Activity

Measured by its binding ability in a functional ELISA.

MW ~120kDa (SDS-PAGE)
Purity ≥98% (SDS-PAGE)
Endotoxin Content <5EU/mg protein (LAL test; Lonza).
Reconstitution Reconstitute 50µg vial in 50µl sterile water.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI reference NP_001008725.2: IL-6Rβ (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

gp130 (also known as Glycoprotein 130, IL6ST, IL6-beta or CD130) is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

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