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IL-6Rβ [GP130] (rat):Fc (human) (rec.)
390
CHF
CHF 390.00
In stock
CHI-RF-311GP130-C05050 µgCHF 390.00
| Product Details | |
|---|---|
| Synonyms | CD130; gp130; Interleukin-6 receptor subunit beta; IL6RB |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of rat IL-6Rβ (aa 23-618) is fused to the N-terminus of the Fc region of human IgG1. |
| Crossreactivity | Rat |
| Biological Activity |
Measured by its binding ability in a functional ELISA. |
| MW | ~120kDa (SDS-PAGE) |
| Purity | ≥98% (SDS-PAGE) |
| Endotoxin Content | <5EU/mg protein (LAL test; Lonza). |
| Reconstitution |
Reconstitute 50µg vial in 50µl sterile water. Add 1X PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Protein Negative Control | |
| Other Product Data |
NCBI reference NP_001008725.2: IL-6Rβ (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
gp130 (also known as Glycoprotein 130, IL6ST, IL6-beta or CD130) is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
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