SYNkinase - Manufacturer of Small Molecule Inhibitors
The Source for High Quality Small Molecule Kinase Inhibitors
SYNkinase is a primary producer of research-use-only biomedical reagents, for life science and drug discovery researchers at universities, research institutes and industry. SYNkinase was established in 2008 with an office in Australia, USA and Europe and research and development laboratories in Shanghai/China. The founders of the company have been involved in pharmaceutical drug discovery for three decades and include kinase biology scientists and expert medicinal and synthetic chemists.
SYNkinase's mission is to provide life science researchers with access to the world's most up-to-date library of kinase inhibitors and other small molecule inhibitors of important therapeutic proteins for drug discovery. SYNkinase offers a library of potent, pure and research-relevant inhibitors directed against specific protein serine/threonine kinases (PS/TKs), protein tyrosine kinases (PTK & RTK) as well as lipid kinases. There are more than 150 kinase targeted drugs in clinical trials or development at present. Twenty-four small molecule inhibitors have been FDA-approved including mTOR, BRaf, MEK, EGFR, JAK, VEGFR and PI3K inhibitors. SYNkinase has many of these compounds available for sale as well as a large range of inhibitors described in the literature such as GPCR, TGF-β, MAP kinase, cell cycle and epigenetic inhibitors. As a primary source manufacturer, SYNkinase maintains a fastidious focus on quality, ensuring that they can consistently supply the same high quality material, as well as being first in the market with the most important and cutting-edge compounds.
AdipoGen Life Sciences offersall SYNkinase Products on an exclusive and in some territories non-exclusive base. Please contact us if you request more information.
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Alpelisib (SYN-1230) - Selective PI3Kα inhibitor with IC50 of 5nM.
Selonsertib (free base) (SYN-1231) - Orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
Olaparib (SYN-3043) - Selectively binds to and inhibits PARP (IC50 of 1-5nM in cell-free assays), inhibiting PARP-mediated repair of single strand DNA breaks.
EPZ005687 (SYN-3050) - Potent and selective inhibitor of the lysine methyltranferase EZH2, the enzymatic subunit of polycomb repressive complex 2 (PRC2) with Ki of 24nM.
KiNet-1 - Unique Pan-Kinase Affinity Tool!
KiNet-1 is a novel, proprietary pan-kinase binder, immobilized on Sepharose beads. The unique pan-kinase affinity of our exclusive CTx-0294885 compound at the heart of KiNet-1 allows it to bind over 200 protein kinases, greatly increasing the coverage of the expressed kinome. The rapid KiNet-1 workflow streamlines interrogation of cell signaling pathways and the identification of novel therapeutic strategies. KiNet-1 can be used as a Western blot pull-down reagent or a mass spec discovery agent. Available in sample sizes of 10, 20 and 50 assays.
|SYNKinase Inhibitor Product Flyer
Including over 60 compounds unique to SYNkinase!
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