ICOS [CD278] – ICOSL [CD275] Pathway


ICOS - ICOSL NetworkInducible T cell co-stimulator (ICOS; CD278) is an activating receptor expressed on the surface of activated cytotoxic T cells, regulatory T cells (Tregs), NK cells and other types of T cells, having a distinct and opposing function than CTLA-4. The ligand ICOSL (B7-H2; CD275) is expressed on antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages. ICOS/ICOSL signaling leads to the activation, proliferation and survival of cytotoxic T cells, as well as the survival of memory T cells. Recently, it has been shown that ICOS expression could be a useful predictive biomarker of response to checkpoint inhibitor treatments (e.g through the CTLA-4 axis).


LIT:  ICOS Co-Stimulation: Friend or Foe? D.J. Wikenheiser & J.S. Stumhofer; Front. Immunol. 7, 304 (2016) • Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy: F. Amatore, et al.; Expert Opin. Ther. Targets 22, 343 (2018)

 

 


Biologically Active ICOS and ICOSL Proteins  

Product Name PID Source Endotoxin Species
ICOSL [B7-H2] (mouse):Fc (mouse) (rec.) CHI-MF-110B7H2 CHO cells <0.06EU/µg Mouse
ICOSL [B7-H2] (mouse):Fc (mouse) (rec.) (non-lytic) CHI-MF-120B7H2 CHO cells <0.06EU/µg Mouse
ICOSL [B7-H2] (human) (rec.) (His) CHI-HF-201B7H2 HEK 293 cells <0.01EU/µg Human
ICOSL [B7-H2] (human):Fc (human) (rec.) CHI-HF-210B7H2 CHO cells <0.06EU/µg Human
ICOSL [B7-H2] (human):Fc (human) (rec.) (non-lytic) CHI-HF-220B7H2 CHO cells <0.06EU/µg Human
ICOSL [B7-H2] (human):Fc (mouse) (rec.) CHI-HF-211B7H2 CHO cells <0.06EU/µg Human
ICOS (mouse):Fc (mouse) (rec.) CHI-MF-110ICOS CHO cells <0.06EU/µg Mouse
ICOS (human):Fc (human) (rec.) CHI-HF-210ICOS CHO cells <0.06EU/µg Human
ICOS (human):Fc (human) (rec.) (non-lytic) CHI-HF-220ICOS CHO cells <0.06EU/µg Human
ICOS (human):Fc (mouse) (rec.) CHI-HF-211ICOS CHO cells <0.06EU/µg Human
Other ICOS and ICOSL Proteins

VALIDATED Antibodies for ICOS and ICOSL Research

 

Product Name PID Isotype Applications Species
ICOSL [B7-H2] (human), mAb (ANC4E3)

ANC-263-020

All Labeled Variants

Mouse IgG1κ ELISA Human
ICOS (human), mAb (ANC6C6)

ANC-265-020

All Labeled Variants

Mouse IgG1κ FACS, FUNC Human


Select Your Pathway of Interest  & Discover High Quality Reagents


© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.