BEZ235

CHF 72.00
In stock
SYN-1018-M0011 mgCHF 72.00
SYN-1018-M0055 mgCHF 108.00
SYN-1018-M01010 mgCHF 156.00
SYN-1018-M05050 mgCHF 198.00
SYN-1018-M100100 mgCHF 356.00
 
More Information
Product Details
Synonyms NVP-BEZ235; BEZ-235
Product Type Chemical
Properties
Formula C30H23N5O
MW 469.6
CAS 915019-65-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: mTOR - PI3K | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.
Product References
  1. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. S.M. Maira, et al.; Mol. Cancer Ther. 7, 1851 (2008)
  2. Recent results in protein kinase inhibition for tropical diseases. D.P. Rotella, et al.; Bioorg. Med. Chem. Lett. 22, 6788 (2012)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.