Bisindolylmaleimide X hydrochloride

CHF 150.00
In stock
SYN-1021-M0011 mgCHF 150.00
SYN-1021-M0055 mgCHF 251.00
SYN-1021-M01010 mgCHF 371.00
SYN-1021-M05050 mgCHF 1'041.00
SYN-1021-M100100 mgCHF 1'514.00
More Information
Product Details
Synonyms Ro 31-8425
Product Type Chemical
Properties
Formula C26H24N4O2 . HCl
MW 424.5 . 36.5
CAS 145317-11-9
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PKC - PLCβ | Kinase Group: AGC | Substrate: Serine-Threonine

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Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key IMBOYWXMTUUYGZ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Bisindoylmaleimide X is a potent and selective protein kinase C (PKC) inhibitor (IC(50) of 15nM for rat brain PKC). It also inhibits Fas-mediated apoptosis and T cell-mediated autoimmune diseases.

Product References
  1. A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)
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