Bosutinib

CHF 60.00
In stock
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More Information
Product Details
Synonyms SKI-606
Product Type Chemical
Properties
Formula C26H29Cl2N5O3
MW 530.5
CAS 380843-75-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Src - Abl | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key UBPYILGKFZZVDX-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Bosutinib is a novel, dual Src/Abl inhibitor with IC(50) values of 1.2nM and 1nM, respectively.
Product References
  1. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity: D.H. Boschelli, et. al.; J. Med. Chem. 44, 3965 (2001)
  2. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice: J.M. Golas, et al.; Cancer Res. 63, 375 (2003)
  3. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models: J.M. Golas, et al.; Cancer Res. 65, 5358 (2005)
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