CI-1040

CHF 60.00
In stock
SYN-1031-M0011 mgCHF 60.00
SYN-1031-M0055 mgCHF 84.00
SYN-1031-M01010 mgCHF 144.00
SYN-1031-M05050 mgCHF 515.00
SYN-1031-M100100 mgCHF 760.00
 
More Information
Product Details
Synonyms PD-184352; CI-1040
Product Type Chemical
Properties
Formula C17H14ClF2IN2O2
MW 478.7
CAS 212631-79-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: MEK - MKK4&7 - MKK3&6 - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GFMMXOIFOQCCGU-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
CI-1040 (PD184352) is an orally active, highly specific, small-molecule inhibitor of MEK1/2, which is a key component of the ERK/MAPK pathway. It has an IC(50) of 17nM.
Product References
  1. Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia: M. Milella, et al.; Blood 99, 3461 (2002)
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