CHF 60.00
In stock
SYN-1051-M0011 mgCHF 60.00
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Product Details
Synonyms KU55933
Product Type Chemical
Formula C21H17NO3S2
MW 395.5
CAS 587871-26-9
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: ATM/ATR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
KU55933 is a potent and selective ATP-competitive inhibitor of ATM, with an IC(50) of 13nM and a Ki of 2.2nM. KU55933 has potential for use as a new radio- and chemo-sensitizing agent for the treatment of cancer.
Product References
  1. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM: I. Hickson, et al.; Cancer Res. 64, 9152 (2004)
  2. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis: J.S. Eaton|et al.; J. Clin. Invest. 117, 2723 (2007)
  3. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy: E. Crescenzi, et al.; Clin. Cancer Res. 14, 1877 (2008)
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