PF-431396

CHF 84.00
In stock
SYN-1063-M0011 mgCHF 84.00
SYN-1063-M0055 mgCHF 144.00
SYN-1063-M01010 mgCHF 251.00
SYN-1063-M05050 mgCHF 910.00
SYN-1063-M100100 mgCHF 1'436.00
 
More Information
Product Details
Synonyms PF431396
Product Type Chemical
Properties
Formula C22H21F3N6O3S
MW 506.5
CAS 717906-29-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PYK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key POJZIZBONPAWIV-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Potent FAK and PYK2 inhibitor. PF431396 has an IC(50) of 31nM against the recombinant PYK2 enzyme.
Product References
  1. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis: L. Buckbinder, et al.; PNAS 104, 10619 (2007)
  2. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design: S. Han, et al.; J. Biol. Chem. 284, 13193 (2009)
  3. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading: K.W. Tse, et al.; J. Biol. Chem. 284, 22865 (2009)
  4. Emerging targets in osteoporosis disease modification: J.G. Allen, et al.; J. Med. Chem. 53, 4332 (2010)
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