PLX4720

CHF 72.00
In stock
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More Information
Product Details
Synonyms PLX-4720
Product Type Chemical
Properties
Formula C17H14ClF2N3O3S
MW 413.8
CAS 918505-84-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: ARaf - Raf - CRaf - BRaf | Kinase Group: TKL | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key YZDJQTHVDDOVHR-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PLX4720 is a potent and selective inhibitor of B-Raf V600E with an IC(50) of 13nM. It is equally potent to c-Raf-1 (Y340D and Y341D mutations), and shows 10-fold selectivity for B-Raf V600E over wild-type B-Raf.
Product References
  1. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity: J. Tsai, et al.; PNAS 105, 3041 (2008)
  2. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression: C. Nucera, et al.; PNAS 107, 10649 (2010)
  3. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer: C. Nucera, et al.; Oncologist 16, 296 (2011)
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