R1487 hydrochloride

CHF 215.00
In stock
SYN-1101-M0011 mgCHF 215.00
SYN-1101-M0055 mgCHF 461.00
SYN-1101-M01010 mgCHF 724.00
SYN-1101-M05050 mgCHF 2'173.00
SYN-1101-M100100 mgCHF 3'226.00
 
More Information
Product Details
Synonyms SY-R1487
Product Type Chemical
Properties
Formula C19H18F2N4O3 . HCl
MW 388.3 . 36.5
CAS 449808-64-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: p38 | Kinase Group: CMGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key RQHSAIGGUWVOBG-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
R1487 is a p38 MAP kinase inhibitor with an IC(50) of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis.
Product References
  1. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase: D.M. Goldstein, et al.; J. Med. Chem. 54, 2255 (2011)
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