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Ponatinib
CHF 72.00
In stock
SYN-1116-M0011 mgCHF 72.00
SYN-1116-M0055 mgCHF 108.00
SYN-1116-M01010 mgCHF 132.00
SYN-1116-M05050 mgCHF 437.00
SYN-1116-M100100 mgCHF 724.00
| Product Details | |
|---|---|
| Synonyms | AP24534 |
| Product Type | Chemical |
| Properties | |
| Formula | C29H27F3N6O |
| MW | 532.6 |
| CAS | 943319-70-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Abl - BCR - FGFR | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Ponatinib is a potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC(50) values of 0.37, 1.1, 1.5, 2.2 and 5.4nM respectively.
Product References
- AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance: T. O'Hare, et al.; Cancer Cell 16, 401 (2009)
- Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant: W.S. Huang, et al.; J. Med. Chem. 53, 4701 (2010)
- Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies: J.M. Gozgit, et al.; Mol. Cancer Ther. 10, 1028 (2011)
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