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VX-745
96
CHF
CHF 96.00
In stock
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| Product Details | |
|---|---|
| Synonyms | VX745 |
| Product Type | Chemical |
| Properties | |
| Formula | C19H9Cl2F2N3OS |
| MW | 436.3 |
| CAS | 209410-46-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: MAPK | Kinase Group: CMGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
VX745 is a selective inhibitor of p38α with an IC(50) of 10nM.
Product References
- The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor: J.P. Duffy, et al.; ACS Med. Chem. Lett. 2, 758 (2011)
- p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils: Y.R. Tsai, et al.; Eur. J. Pharmacol. 701, 96 (2013)
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