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VX-745
96
CHF
CHF 96.00
In stock
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Product Details | |
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Synonyms | VX745 |
Product Type | Chemical |
Properties | |
Formula | C19H9Cl2F2N3OS |
MW | 436.3 |
CAS | 209410-46-8 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: MAPK | Kinase Group: CMGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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VX745 is a selective inhibitor of p38α with an IC(50) of 10nM.
Product References
- The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor: J.P. Duffy, et al.; ACS Med. Chem. Lett. 2, 758 (2011)
- p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils: Y.R. Tsai, et al.; Eur. J. Pharmacol. 701, 96 (2013)