VX-745

CHF 96.00
In stock
SYN-1123-M0011 mgCHF 96.00
SYN-1123-M0055 mgCHF 156.00
SYN-1123-M01010 mgCHF 227.00
SYN-1123-M05050 mgCHF 742.00
SYN-1123-M100100 mgCHF 1'317.00
 
More Information
Product Details
Synonyms VX745
Product Type Chemical
Properties
Formula C19H9Cl2F2N3OS
MW 436.3
CAS 209410-46-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: MAPK | Kinase Group: CMGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key VEPKQEUBKLEPRA-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
VX745 is a selective inhibitor of p38α with an IC(50) of 10nM.
Product References
  1. The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor: J.P. Duffy, et al.; ACS Med. Chem. Lett. 2, 758 (2011)
  2. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils: Y.R. Tsai, et al.; Eur. J. Pharmacol. 701, 96 (2013)
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