CHF 96.00
In stock
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Product Details
Synonyms HKI-272
Product Type Chemical
Formula C30H29ClN6O3
MW 557.0
CAS 698387-09-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: EGFR | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC(50) values of 59nM and 92nM for HER2 and EGFR, respectively. It is in development for the treatment of early- and late-stage HER2-positive breast cancer.
Product References
  1. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase: S.K. Rabindran, et al.; Cancer Res. 64, 3958 (2004)
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