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JNJ-28312141
CHF 227.00
In stock
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| Product Details | |
|---|---|
| Synonyms | JNJ28312141 |
| Product Type | Chemical |
| Properties | |
| Formula | C26H32N6O2 |
| MW | 460.6 |
| CAS | 885692-52-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: CSF1R, FLT3 | Kinase Group: CMGC | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GUBJNPWVIUFSTR-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
JNJ-28312141 is an orally active tyrosine kinase inhibitor for FMS with an IC(50) of 0.69nM and a cell assay IC(50) of 2.6nM. It is an active CSF1R inhibitor (Colony-stimulating factor-1 receptor) and also a FLT3 inhibitor.
Product References
- JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia: C.L. Manthey, et al.; Mol. Cancer Ther. 8, 3151 (2009)
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