PD-0173074

CHF 60.00
In stock
SYN-1176-M0011 mgCHF 60.00
SYN-1176-M0055 mgCHF 84.00
SYN-1176-M01010 mgCHF 120.00
 
More Information
Product Details
Synonyms PD0173074
Product Type Chemical
Properties
Formula C28H41N7O3
MW 523.7
CAS 219580-11-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: VEGFR2 - FGFR1 | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key DXCUKNQANPLTEJ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PD173074 is a potent FGFR1 inhibitor with IC(50) of approximately 25nM and also inhibits VEGFR2 with an IC(50) of 100-200nM.
Product References
  1. Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells: R. Bansal, et al.; J. Neurosci. Res. 74, 486 (2003)
  2. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma: S. Trudel, et al.; Blood 103, 3521 (2004)
  3. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest: M. Miyake, et al.; J. Pharmacol. Exp. Ther. 332, 795 (2010)
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