Palbociclib dihydrochloride

CHF 72.00
In stock
SYN-1180-M0011 mgCHF 72.00
SYN-1180-M0055 mgCHF 120.00
SYN-1180-M01010 mgCHF 168.00
SYN-1180-M05050 mgCHF 431.00
SYN-1180-M100100 mgCHF 778.00
 
More Information
Product Details
Synonyms PD-0332991
Product Type Chemical
Properties
Formula C24H29N7O2 . 2HCl
MW 447.5 . 72.9
CAS 571189-11-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Abl - CDK2 - CDK4 - CDK5 - CDK7 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key YORIVNBSTFKZTO-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Palbociclib is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC(50)values of 11nM and 16nM, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR.
Product References
  1. PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity: J.E. Logan, et al.; Anticancer Res. 33, 2997 (2013)
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