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AST-487
108
CHF
CHF 108.00
In stock
SYN-1210-M0011 mgCHF 108.00
SYN-1210-M0055 mgCHF 263.00
SYN-1210-M01010 mgCHF 419.00
SYN-1210-M05050 mgCHF 1'077.00
SYN-1210-M100100 mgCHF 1'796.00

Product Details | |
---|---|
Synonyms | AST487 |
Product Type | Chemical |
Properties | |
Formula | C26H30F3N7O2 |
MW | 529.6 |
CAS | 630124-46-8 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Slightly soluble (< 1mg/mL) in DMSO. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: Flt3 | Kinase Group: TK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | ODPGGGTTYSGTGO-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML.
Product References
- Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells: E. Weisberg, et al.; Blood 112, 5161 (2008)