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AST-487
CHF 108.00
In stock
SYN-1210-M0011 mgCHF 108.00
SYN-1210-M0055 mgCHF 263.00
SYN-1210-M01010 mgCHF 419.00
SYN-1210-M05050 mgCHF 1'077.00
SYN-1210-M100100 mgCHF 1'796.00
| Product Details | |
|---|---|
| Synonyms | AST487 |
| Product Type | Chemical |
| Properties | |
| Formula | C26H30F3N7O2 |
| MW | 529.6 |
| CAS | 630124-46-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Slightly soluble (< 1mg/mL) in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Flt3 | Kinase Group: TK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | ODPGGGTTYSGTGO-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML.
Product References
- Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells: E. Weisberg, et al.; Blood 112, 5161 (2008)
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