PF-05274857 hydrochloride

CHF 174.00
In stock
SYN-3008-M0011 mgCHF 174.00
SYN-3008-M0055 mgCHF 299.00
SYN-3008-M01010 mgCHF 515.00
SYN-3008-M05050 mgCHF 1'903.00
SYN-3008-M100100 mgCHF 2'861.00
 
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Product Details
Synonyms PF05274857
Product Type Chemical
Properties
Formula C20H25ClN4O3S . HCl
MW 436.9 . 36.5
CAS 1613439-62-5
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO, DMF or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Smo | Kinase Group: N/A | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GULNFUQAVPTTQV-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
PF-5274857 is a potent and selective Smoothened (Smo) antagonist with an IC(50) and Ki of 5.8nM and 4.6nM, respectively.
Product References
  1. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier: A. Rohner, et al.; Mol. Cancer Ther. 11, 57 (2012)
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