Prazosin hydrochloride

CHF 60.00
In stock
SYN-3017-M0011 mgCHF 60.00
SYN-3017-M0055 mgCHF 78.00
SYN-3017-M01010 mgCHF 90.00
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Product Details
Synonyms Minipress; Vasoflex; Pressin
Product Type Chemical
Formula C19H21N5O4 . HCl
MW 383.4 . 36.5
CAS 19237-84-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: α-1 receptors - MT3 receptor | Kinase Group: N/A | Substrate: N/A

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Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Prazosin hydrochloride, a quinazoline derivative, is the first of a new chemical class of anti-hypertensives. Prazosin hydrochloride is a selective adrenergic α-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud disease, prostatic hypertrophy and urinary retention. The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscles. Animal studies suggest that the vasodilator effect of prazosin is related to blockade of postsynaptic alpha-adrenoceptors. Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by reflex tachycardia.

Product References
  1. Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus: D.S. Pickering & L.P. Niles; Eur. J. Pharmacol. 175, 71 (1990)
  2. Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens: J.M. Mathé, et al.; Eur. J. Pharmacol. 309, 1 (1996)
  3. Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs: P. Paul, et al.; J. Pharmacol. Exp. Ther. 290, 334 (1999)
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