Ziprasidone hydrochloride hydrate

CHF 60.00
In stock
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Product Details
Synonyms Geodon
Product Type Chemical
Properties
Formula C21H21ClN4OS . HCl . H2O
MW 412.9 . 36.5 . 18.0
CAS 138982-67-9
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: 5-HT2A | Kinase Group: N/A | Substrate: N/A

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Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key ZCBZSCBNOOIHFP-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
Ziprasidone is a antipsychotic drug used for the treatment of schizophrenia, acute mania and mixed states associated with bipolar disorder. It is a potent drug with mostly submicromolar IC50 values for principal targets. Ziprasidone is a 5HT1A/5HT2A antagonist (Ki=0.6nm for 5HT2A, Ki=2.3nM for 5HT1d), but has reasonably low Ki values for Dopamine D1-D5 receptors (Ki=7-152nM) and other receptors like α 1A adrenergic receptors (Ki=18nM), Histamine 1 receptor (Ki=63nm), and 5-HT transporter (Ki=53nm), as well.
Product References
  1. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex: H. Rollema, et al.; Biol. Psychiatry 48, 229 (2000)
  2. Structural mechanism for statin inhibition of HMG-CoA reductase: E.S. Istvan & J. Deisenhofer; Science 292, 1160 (2001)
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