Atorvastatin calcium salt

CHF 60.00
In stock
SYN-3020-M0011 mgCHF 60.00
SYN-3020-M0055 mgCHF 78.00
SYN-3020-M01010 mgCHF 90.00
SYN-3020-M05050 mgCHF 132.00
SYN-3020-M100100 mgCHF 227.00
 
More Information
Product Details
Synonyms Lipitor
Product Type Chemical
Properties
Formula (C33H34FN2O5)2 . Ca
MW 1115.2 . 40.1
CAS 134523-03-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: HMG-CoA reductase | Kinase Group: N/A | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key XUKUURHRXDUEBC-KAYWLYCHSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels. IC(50) values are in the low nanomolar range with cytotoxicity values being largely in the low micromolar range.
Product References
  1. Update on statins: 2003: C.J. Vaughan & A.M. Gotto; Circulation 110, 886 (2004)
  2. Atorvastatin inhibits inflammatory hypernociception: T. Santodomingo-Garzón, et al.; Br. J. Pharmacol. 149, 14 (2006)
  3. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: N.A. Turner, et al.; J. Cardiovasc. Pharmacol. 50, 458 (2007)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.