Atorvastatin calcium salt

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Product Details
Synonyms Lipitor
Product Type Chemical
Formula (C33H34FN2O5)2 . Ca
MW 1115.2 . 40.1
CAS 134523-03-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: HMG-CoA reductase | Kinase Group: N/A | Substrate: N/A

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Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels. IC(50) values are in the low nanomolar range with cytotoxicity values being largely in the low micromolar range.

Product References
  1. Update on statins: 2003: C.J. Vaughan & A.M. Gotto; Circulation 110, 886 (2004)
  2. Atorvastatin inhibits inflammatory hypernociception: T. Santodomingo-Garzón, et al.; Br. J. Pharmacol. 149, 14 (2006)
  3. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: N.A. Turner, et al.; J. Cardiovasc. Pharmacol. 50, 458 (2007)
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