Nelfinavir mesylate

CHF 60.00
In stock
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Product Details
Synonyms AG 1341
Product Type Chemical
Properties
Formula C32H45N3O4S . CH4O3S
MW 567.8 . 96.1
CAS 159989-65-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: N/A | Kinase Group: N/A | Substrate: N/A

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InChi Key NQHXCOAXSHGTIA-SKXNDZRYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
Nelfinavir is an anti-retroviral drug used in the treatment of the human immunodeficiency virus (HIV). It is a potent HIV protease inhibitor with potent antiviral activity (95% effective dose = 0.04µg/ml) against a number of HIV-1 strains in acute and chronic models of infection. Nelfinavir is an effective anti-cancer agent, with an EC50 of 3.1-5.2µM and induced apoptosis and autophagic responses. It mediates AKT signaling demonstrating inhibition of endogenous and growth factor-induced Akt activation. Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy and apoptosis.
Product References
  1. Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients: H.G. Schaefer, et al.; Antimicrob. Agents Chemother. 40, 29 (1996)
  2. Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease: B.V. Shetty, et al.; Antimicrob. Agents Chemother. 40, 110 (1996)
  3. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo: J.J. Gills, et al.; Clin. Cancer Res. 13, 5183 (2007)
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