Exemestane

CHF 60.00
In stock
SYN-3023-M0011 mgCHF 60.00
SYN-3023-M0055 mgCHF 78.00
SYN-3023-M01010 mgCHF 84.00
SYN-3023-M05050 mgCHF 311.00
SYN-3023-M100100 mgCHF 527.00
 
More Information
Product Details
Synonyms FCE 24304
Product Type Chemical
Properties
Formula C20H24O2
MW 296.4
CAS 107868-30-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Aromatase | Kinase Group: N/A | Substrate: N/A

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InChi Key BFYIZQONLCFLEV-DAELLWKTSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Exemestane (6-methylenandrosta-1,4-diene-3,17-dione; FCE 24304) is an orally active irreversible aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane inhibits human placental and rat ovarian aromatase with IC50 values of 30nM and 40nM, respectively.
Product References
  1. Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione): F. Buzzetti, et al.; Steroids. 58, 527 (1993)
  2. Novel aromatase inhibitors by structure-guided design: D. Ghosh, et al. J. Med. Chem. 55, 8464 (2012)
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