CHF 60.00
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SYN-3023-M0011 mgCHF 60.00
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Product Details
Synonyms FCE 24304
Product Type Chemical
Formula C20H24O2
MW 296.4
CAS 107868-30-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Aromatase | Kinase Group: N/A | Substrate: N/A

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Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Exemestane (6-methylenandrosta-1,4-diene-3,17-dione; FCE 24304) is an orally active irreversible aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane inhibits human placental and rat ovarian aromatase with IC50 values of 30nM and 40nM, respectively.

Product References
  1. Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione): F. Buzzetti, et al.; Steroids. 58, 527 (1993)
  2. Novel aromatase inhibitors by structure-guided design: D. Ghosh, et al. J. Med. Chem. 55, 8464 (2012)
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