Glyburide

CHF 60.00
In stock
SYN-3026-M0011 mgCHF 60.00
SYN-3026-M0055 mgCHF 78.00
SYN-3026-M01010 mgCHF 90.00
 
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Product Details
Synonyms Diabeta; Glibenclamide
Product Type Chemical
Properties
Formula C23H28ClN3O5S
MW 494.0
CAS 10238-21-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: SUR1 | Kinase Group: | Substrate: N/A

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InChi Key ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
Glyburide (Diabeta) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agent. Works by binding to and activating the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1) in pancreatic beta-cells. This inhibition causes cell membrane depolarization opening voltage-dependent calcium channel. This results in an increase in intracellular calcium in the beta-cell and subsequent stimulation of insulin release. Recently it was shown to improve the outcome in animal stroke models by preventing brain swelling and enhancing neuroprotection. Shown to be a NLRP3 inflammasome inhibitor.
Product References
  1. Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects: J.M. Feldman; Pharmacotherapy 5, 43 (1985)
  2. The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells: H. Schmid-Antomarchi, et al.; J. Biol. Chem. 262, 15840 (1987)
  3. Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels: M. Fosset, et al.; J. Biol. Chem. 263, 7933 (1988)
  4. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome: M. Lamkanfi, et al.; J. Cell. Biol. 187, 61 (2009)
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