CHF 60.00
In stock
SYN-3043-M0011 mgCHF 60.00
SYN-3043-M0055 mgCHF 96.00
SYN-3043-M01010 mgCHF 144.00
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Product Details
Synonyms AZD-2281; KU-59436; 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one
Product Type Chemical
Formula C24H23FN4O3
MW 434.2
CAS 763113-22-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PARP | Kinase Group: N/A | Substrate: N/A
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The PARP inhibitor Olaparib (AZD2281) is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing and antineoplastic activities. Olaparib selectively binds to and inhibits PARP (IC50 of 1-5nM in cell-free assays), inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

Product References
  1. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1: K.A. Menear, et al.; J. Med. Chem. 51, 6581 (2008)
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