Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Olaparib
CHF 60.00
In stock
SYN-3043-M0011 mgCHF 60.00
SYN-3043-M0055 mgCHF 96.00
SYN-3043-M01010 mgCHF 144.00
SYN-3043-M05050 mgCHF 419.00
SYN-3043-M100100 mgCHF 658.00
| Product Details | |
|---|---|
| Synonyms | AZD-2281; KU-59436; 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one |
| Product Type | Chemical |
| Properties | |
| Formula | C24H23FN4O3 |
| MW | 434.2 |
| CAS | 763113-22-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PARP | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
The PARP inhibitor Olaparib (AZD2281) is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing and antineoplastic activities. Olaparib selectively binds to and inhibits PARP (IC50 of 1-5nM in cell-free assays), inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.
Product References
- 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1: K.A. Menear, et al.; J. Med. Chem. 51, 6581 (2008)
Related Products
