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Olaparib
60
CHF
CHF 60.00
In stock
SYN-3043-M0011 mgCHF 60.00
SYN-3043-M0055 mgCHF 96.00
SYN-3043-M01010 mgCHF 144.00
SYN-3043-M05050 mgCHF 419.00
SYN-3043-M100100 mgCHF 658.00
| Product Details | |
|---|---|
| Synonyms | AZD-2281; KU-59436; 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one |
| Product Type | Chemical |
| Properties | |
| Formula | C24H23FN4O3 |
| MW | 434.2 |
| CAS | 763113-22-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: PARP | Kinase Group: N/A | Substrate: N/A |
| InChi Key | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
The PARP inhibitor Olaparib (AZD2281) is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing and antineoplastic activities. Olaparib selectively binds to and inhibits PARP (IC50 of 1-5nM in cell-free assays), inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.
Product References
- 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1: K.A. Menear, et al.; J. Med. Chem. 51, 6581 (2008)
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