Cymax TRAIL (human) ELISA Kit

CHF 450.00

In stock

YIF-LF-EK02661 x 96 wellsCHF 450.00

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Product Details
Synonyms	CD253; APO2L; Apo-2L; TNFSF10; Apo-2 Ligand; Protein TRAIL; TNF-related Apoptosis-inducing Ligand; Tumor Necrosis Factor Ligand Superfamily Member 10
Product Type	Kit
Properties
Application Set	Compound Screening
Crossreactivity	Human
Quantity	1x96 wells
Sensitivity	0.065 pg/ml
Range	31.25 pg/ml - 1500 pg/ml
Sample Type	Buffers Cell Culture Supernatant Cell Lysate Plasma Serum
Assay Type	Sandwich
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by AbFrontier
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Any unused reconstituted standard should be discarded or frozen at -80℃. Standard can be frozen and thawed one time only without loss of immunoreactivity.
Documents
Manual	Download PDF
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Description

TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to fi ve distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2;TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducingthe formation of the so-called multiprotein death-inducing signaling complex (DISC).

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